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1

Is inhibition of kinase activity the only therapeutic strategy forLRRK2-associated Parkinson's disease?

Iakov N Rudenko, Ruth Chia, Mark R Cookson

Journal:

Year:

2012

Language:

english

File:

PDF, 245 KB

english, 2012

2

mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex

Dillman, Allissa A, Hauser, David N, Gibbs, J Raphael, Nalls, Michael A, McCoy, Melissa K, Rudenko, Iakov N, Galter, Dagmar, Cookson, Mark R

Journal:

Nature Neuroscience

Year:

2013

Language:

english

File:

PDF, 846 KB

english, 2013

3

The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation

Rudenko, Iakov N., Kaganovich, Alice, Hauser, David N., Beylina, Aleksandra, Chia, Ruth, Ding, Jinhui, Maric, Dragan, Jaffe, Howard, Cookson, Mark R.

Journal:

Biochemical Journal

Year:

2012

Language:

english

File:

PDF, 1.79 MB

english, 2012

4

Heterogeneity of Leucine-Rich Repeat Kinase 2 Mutations: Genetics, Mechanisms and Therapeutic Implications

Rudenko, Iakov N., Cookson, Mark R.

Journal:

Neurotherapeutics

Year:

2014

Language:

english

File:

PDF, 1.99 MB

english, 2014

5

Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7

Chia, Ruth, Haddock, Sara, Beilina, Alexandra, Rudenko, Iakov N., Mamais, Adamantios, Kaganovich, Alice, Li, Yan, Kumaran, Ravindran, Nalls, Michael A., Cookson, Mark R.

Journal:

Nature Communications

Year:

2014

Language:

english

File:

PDF, 1.89 MB

english, 2014

6

Is Inhibition of Kinase Activity the Only Therapeutic Strategy for LRRK2-associated Parkinson's Disease?

Rudenko, Iakov N, Chia, Ruth, Cookson, Mark R

Journal:

Year:

2012

Language:

english

File:

PDF, 329 KB

english, 2012

7

Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle

Lobbestael, Evy, Zhao, Jing, Rudenko, Iakov N., Beylina, Aleksandra, Gao, Fangye, Wetter, Justin, Beullens, Monique, Bollen, Mathieu, Cookson, Mark R., Baekelandt, Veerle, Nichols, R. Jeremy, Taymans,

Journal:

Biochemical Journal

Year:

2013

Language:

english

File:

PDF, 1.59 MB

english, 2013

8

14-3-3 proteins are promising LRRK2 interactors

Rudenko, Iakov N., Cookson, Mark R.

Journal:

Biochemical Journal

Year:

2010

Language:

english

File:

PDF, 77 KB

english, 2010

9

Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation

Liu, Guoxiang, Yu, Jia, Ding, Jinhui, Xie, Chengsong, Sun, Lixin, Rudenko, Iakov, Zheng, Wang, Sastry, Namratha, Luo, Jing, Rudow, Gay, Troncoso, Juan C., Cai, Huaibin

Journal:

Journal of Clinical Investigation

Year:

2014

Language:

english

File:

PDF, 5.45 MB

english, 2014

10

The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2

Rudenko, Iakov N., Kaganovich, Alice, Langston, Rebekah G., Beilina, Aleksandra, Ndukwe, Kelechi, Kumaran, Ravindran, Dillman, Allissa A., Chia, Ruth, Cookson, Mark R.

Journal:

Biochemical Journal

Year:

2017

Language:

english

File:

PDF, 1.88 MB

english, 2017

11

Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice

Pellegrini, Laura, Hauser, David N, Li, Yan, Mamais, Adamantios, Beilina, Alexandra, Kumaran, Ravindran, Wetzel, Andrea, Heaton, George, Rudenko, Iakov, Alkaslasi, Mor, Ivanina, Natalie, Melrose, Heat

Journal:

Human Molecular Genetics

Year:

2018

Language:

english

File:

PDF, 1.57 MB

english, 2018

12

Differences in Stability, Activity and Mutation Effects Between Human and Mouse Leucine-Rich Repeat Kinase 2

Langston, Rebekah G., Rudenko, Iakov N., Kumaran, Ravindran, Hauser, David N., Kaganovich, Alice, Ponce, Luis Bonet, Mamais, Adamantios, Ndukwe, Kelechi, Dillman, Allissa A., Al-Saif, Amr M., Beilina,

Journal:

Neurochemical Research

Year:

2018

Language:

english

File:

PDF, 3.10 MB

english, 2018